オリゴヌクレオチド受託合成修飾の種類

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目次

• Shanghai Generay Biotech
• Bio-Synthesis

修飾されたオリゴヌクレオチド (修飾DNAおよび修飾RNA)は、数多くの生化学反応やプロセスのメカニズムや立体化学的側面の理解に役立っています。バイオシンセシス社では、固相化学合成法や酵素アシスト法を用いて、骨格、塩基、糖、ヌクレオチド間結合を含む人工的な修飾オリゴヌクレオチドを得ることができる高品質なカスタムオリゴ修飾サービスを提供しています。

見積もりのご依頼はこちら | DNA合成 | RNA合成

オリゴヌクレオチドの修飾ラインナップ参考価格の一例

PAGEかHPLCのいずれかをお選び下さい。これ以外の供給量もお選び頂けます。以下は参考料金ですので、見積もりをご用命ください。

DeoxyInosine | DeoxyUridine | Phosphorylation | Attachment Chemistry & Linkers | Fluorophores | Dark Quenchers | Dual-Labeled DNA Probes | Molecular Beacons

デオキシイノシン・デオキシウリジン

リン酸化

蛍光色素・その他

両末端標識プローブ

Bio-Synthesis社で合成する場合

長年にわたる多くの実績を持つBio-Synthesis Inc (Texas)によるサービスです。
バイオシンセシス社の統合されたFlexOligo合成プラットフォームは、化学合成の効率を高めることで大幅なコスト削減をもたらし、短期間での大幅なスケールアップ生産を可能にします。同社は、ホスホジエステル骨格、プリンおよびピリミジン複素環塩基などの複雑なオリゴヌクレオチド修飾を得意としています。
各料金についてはお気軽にお問い合わせください。

以下のリンク先メーカーサイトで詳細をご確認頂けます。

Backbone Modification

弊社ではBNA関連の製品は取り扱っておりません。

• バックボーン修飾オリゴヌクレオチドの合成について
• 2′ O-Methyl RNA (2′ Me)
• L-DNA, L-RNA
• Methyl Phosphonamidite
• Methyl Phosphonate
• P-Ethoxy
• Phosphonoacetate PACE DNA
• Phosphorothioate DNA, Phosphorothioate RNA
• ZNA Spermine

Modified Base

• 修飾塩基オリゴについて
• 2′-Deoxyribonucleoside Purine Modified Bases
  • 2,6-Diaminopurine-2′-deoxyriboside (DAPdR) | 2-Aminopurine-2′-deoxyriboside | 3-deaza-2′-deoxyadenosine, 3-deaza-dA | 6-Thio-2′-deoxyguanosine | 7-Deaza-2′-deoxyadenosine, 7-Deaza-dA | 7-deaza-2′-deoxyguanosine, 7-Deaza-dG | 7-Deaza-2′-deoxyxanthosine, 7-Deaza-dX | 7-Deaza-8-aza-dA DNA | 7-deaza-8-aza-dG DNA | 8-5′(5’S)-Cyclo-2′-deoxyadenosine, Cyclo-dA | 8-5′(5’S)-Cyclo-2′-deoxyguanosine, Cyclo-dG | 8-Amino-2′-deoxyadenosine, 8-Amino-dA | 8-Amino-2′-deoxyguanosine, 8-Amino-dG | 8-Bromo-2′-deoxyadenosine, 8-Br-dA | 8-Bromo-2′-deoxyguanosine | 8-Deuterated-2′-deoxyguanosine | 8-OMethyl Deoxyguanosine, 8-OMe-dG | 8-Oxo-2′-deoxyadenosine | 8-Oxo-2′-deoxyguanosine | Etheno-2′-deoxyadenosine | Formylindole | isoGuanosine (iso-dG) | N1-Methyl-deoxyadenosine, N1-Me-dA | N2-Methyl-2′-Deoxyguanosine (N2-Methyl-dG) | N6-Methyl-2′-deoxyadenosine, N6-Methyl-dA | O6-Methyl-2′-deoxyguanosine | O6-Phenyl-2’deoxyinosine
• 2′-Deoxyribonucleoside Pyrimidine Modified Bases
  • 2′,2′-Difluorodeoxycytidine (Gemcitabine) dFdC | 2′-Deoxypseudouridine | 2-Thiothymidine | 4-Thio-2′-deoxyuridine | 4-Thiothymidine, 4-Thio-dT (S4dT) | 5′ Aminothymidine | 5,6-Dihydro-2′-deoxyuridine, Dihdyro-dU | 5,6-Dihydrothymidine, Dihydro-dT | 5-Bromo deoxycytosine, 5-Br-dC | 5-Bromo deoxyuridine, 5-Br-dU | 5-Bromo-2′-deoxyuridine | 5-Fluoro-2′-deoxyuridine, 5-F-dU | 5-Formyl-2′-deoxycytidine | 5-Hydroxy-2′-deoxycytidine | 5-Hydroxy-2′-deoxyuridine | 5-Hydroxymethyl-2′-deoxycytidine | 5-Hydroxymethyl-2′-deoxyuridine | 5-Iodo-2′-deoxycytidine | 5-Iodo-2′-deoxyuridine, 5-Iodo-dU | 5-Methyl-2′-deoxycytidine, 5-Methyl-dC | 5-Methyl-2′-deoxyisocytidine | 5-Propynyl-2′-deoxycytidine | 5-Propynyl-2′-deoxyuridine | C4-(1,2,4-Triazol-1-yl)-2′-deoxyuridine | dT Ferrocene | EDTA 2′-Deoxyuridine | N3-Ethyl deoxy Cytidine | N3-Methyl deoxy Cytidine | N3-Methyl deoxy Thymidine | N4-Ethyl-2′-deoxycytidine | O4-(TMP)-5-F-2′-deoxyuridine | O4-Methylthymidine | Perylene-dU Fluorescent Base | Pyrene-dU Fluorescent Base | Pyrrolo-2′-deoxycytidine | Thymidine Glycol
• 2′-O-Methyl Ribonucleoside Modified Bases
  • 2,6-Diaminopurine-2′-O-methylriboside | 2-Aminopurine-2′-O-methylriboside | 2′-O-Methylinosine, 2′-OMe-I | 3-Deaza-5-Aza-2′-O-methylcytidine | 5-Bromo-2′-O-Methyluridine, 2′-OMe-5-Br-U | 5-Fluoro-2′-OMethyl Uridine, 2′-OMe-5-F-U | 5-Fluoro-2′-O-Methyluridine | 5-Fluoro-4-O-TMP-2′-O-Methyluridine, 2′-OMe-TMP-5-F-U | 5-Methyl-2′-O-Methylcytidine, 2′-OMe-5-Me-C | 5-Methyl-2′-O-Methylthymidine | 5-Methyl-2′-O-MethylUridine, 2′-OMe-5-Me-U
• Ribonucleoside Modified Bases
  • 2′ Fluoro RNA | 2,6-Diaminopurine-riboside | 2-Aminopurine-Ribose | 2′-F-arabinonucleic acid (2′-F-ANA) | 4-Thiouridine, 4-Thio-Uridine RNA | 5-Bromouridine, 5-Bromo-Uridine, 5-Br-U | 5-Iodouridine, 5-Iodo-Uridine | 5-Methylcytosine, 5-Methyl-Cytidine, 5-Me-C | 5-Methyluridine, 5-Me-U | 6-Thio-Guanosine, 6-Thio G RNA | 7-Deaza-Adenosine, 7-Deaza-A RNA | 8-Aza-7-Deaza-Adenosine, 8-Aza-7-Deaza A RNA | 8-Oxo-Guanosine, 8-Oxo-rG | Inosine Ribose | N1-Methyl Adenosine, N1-Me-rA | Nebularine RNA | Pseudouridine RNA | Puromycin | Pyridin-2-One Ribonucleoside | Pyrrolocytidine, Pyrrolo-Cytidine,Pyrrolo-C | Thio-2-dT, S2dT | Zebularine RNA
• Sugar Modified Bases
  • 2′,3′-Dideoxyadenosine, ddA | 2′,3′-Dideoxycytidine, ddC | 2′,3′-Dideoxyguanosine, ddG | 2′,3′-Dideoxythymidine, ddT | 2′-Amino Aminopyrimidine RNA Base | 3′-Deoxyadenosine, Cordycepin,2′-5′ Linked | 3′-Deoxycytidine, 2′-5′ Linked | 3′-Deoxyguanosine, 2′-5′ Linked | 3′-Deoxythymidine, 2′-5′ Linked | 3′-Riboadenosine, 2′-5′ Linked | 3′-Ribocytidine, 2′-5′ Linked | 3′-Riboguanosine, 2′-5′ Linked | 3′-Ribouridine, 2′-5′ Linked | 5′-Iodothymidine, 5′-I-T | 5′-OMethyl Deoxyadenosine, 5′-OMe-dA | 5′-OMethyl Deoxyguanosine, 5′-OMe-dG | 5′-O-Methylthymidine | Araadenosine, Ara-A | Aracytidine, Ara-C | Araguanosine, Ara-G | Arauridine, Ara-U
• Wobble and Universal Bases
  • 2′ Deoxynebularine, dN | 2′-Deoxyinosine | 2′-Deoxyisoguanosine | 5-Nitroindole-2′-deoxyriboside | K-2′-deoxyribose, dK | P-2′-deoxyribose, dP | Pyrrolidine Universal Base | Wobble Site, Degenerate Site

Inverted Bases

• Inverted塩基オリゴについて
• 3′-3′ & 5′-5′ Reverse Linked Oligonucleotide

Crossking and Ligation

• 架橋塩基修飾オリゴについて
• 2-Fluoro deoxy Inosine dl (convertible dG)
• 3-cyanovinylcarbazole nucleoside CNVK Ultrafast Photo Cross-Linker
• 5-lodo deoxycytosine dC
• 5-lodo deoxyuridine dU
• DNP-TEG
• Psoralen C2 & C6

Cross Linker Modifications

• リンカーの付加について
• Amino Linkers
  • 2′-Deoxycytidine-5-C6 Amino Linker (Amino C6-dC) | 2′-Deoxyguanosine-8-C6 Amino Linker (2′-dG-C6-NH2) | 8-Amino C6 dA Oligo Modification | Amino 7 Linker | Amino C12 Linker | Amino C3 Linker | Amino C6 deoxyadenosine (Amino C6-dA) | Amino C6 Linker | Amino C6 U | Amino Linker AMC | Amino TEG | Amino Serinol | Prolinol Amino C6 | Thymidine-5-C6 Amino Linker (Amino C6-dT) | Thymine-5-C2 Amino Linker (Amino C2-dT)
• Carbonyl-reactive Crosslinker
  • Alkoxyamine | Hydrazide
• Carboxy Linkers
  • 3′ Carboxy Linker | 5-Carboxy-2′-deoxycytidine, 5-Carboxy-dC | DADE Carboxy C10 Linkers | dT-Carboxy
• Other Linkers
  • Acrydite | Aldehyde | Aniline | Cholesteryl TEG | Formylbenzamide | Glyceryl | Maleimide
• Thiol Linkers
  • 3′ Thiol C3 Linkers | Dithiol (DTPA) Linker | Thiol C6 dT | Thiol C6 Linkers

Spacer

• スペーサー修飾オリゴヌクレオチド合成について
• Azido PEG12, PEG24, PEG3
• C12 Spacer, C3 Spacer, C6 Spacer, C9 Spacer
• dSpacer (Abasic Furan)
• Ribo rSpacer
• Spacer 18 (Hexaethylene glycol)
• Spacer 9

Fluorescent Labeled Oligos

• Abberior Dye
  • Abberior CAGE 500 Fluor Dye | Abberior CAGE 532 Fluor Dye | Abberior CAGE 552 Fluor Dye | Abberior FLIP 565 Fluor Dye | Abberior STAR 440SX Fluor Dye | Abberior STAR 488 Fluor Dye | Abberior STAR 512 Fluor Dye | Abberior STAR 580 Fluor Dye | Abberior STAR 635 Fluor Dye | Abberior STAR 635P Fluor Dye
• Alexa Fluor Dye
  • Alexa 350 | Alexa 405 | Alexa 430 | Alexa 488 | Alexa 514 | Alexa 532 | Alexa 546 | Alexa 555 | Alexa 568 | Alexa 594 | Alexa 610 | Alexa 633 | Alexa 635 | Alexa 647 | Alexa 660 | Alexa 700 | Alexa 750
• ATTO Fluor Dye
  • ATTO 390 | ATTO 425 | ATTO 465 | ATTO 488 | ATTO 495 | ATTO 514 | ATTO 520 | ATTO 532 | ATTO 542 | ATTO 550 | ATTO 565 | ATTO 590 | ATTO 594 | ATTO 610 | ATTO 620 | ATTO 633 | ATTO 643 | ATTO 647 | ATTO 647N | ATTO 655 | ATTO 665 | ATTO 680 | ATTO 700 | ATTO 725 | ATTO 740 | ATTO Oxa12 | ATTO Rho101 | ATTO Rho11 | ATTO Rho110 | ATTO Rho12 | ATTO Rho13 | ATTO Rho14 | ATTO Rho3B | ATTO Rho6G | ATTO Thio12
• BODIPY Fluor Dye
  • BODIPY 493/503 | BODIPY 530/550 | BODIPY 558/568 | BODIPY 564/570 C3 | BODIPY 576/589 | BODIPY 581/591 | BODIPY 630/650 | BODIPY 650/665 | BODIPY FL | BODIPY R6G | BODIPY TMR | BODIPY TR
• Chromeo Dyes
• Cyanine
  • Cy3 Dye | Cy3.5 Dye | Cy3B Dye | Cy5 Dye | Cy5.5 Dye | Cy7 Dye | Cyan 500
• DyLight Dye Oligo Labeling
  • DyLight 350 | DyLight 405 | DyLight 550 | DyLight 594 | DyLight 633 | DyLight 650 | DyLight 680 | DyLight 755 | DyLight 800
• Dyomics
  • Dyomic 350 UV Excitation | Dyomic DY-350XL UV-MegStokes | Dyomic DY-360XL UV-MegStokes | Dyomic DY-370XL UV-MegStokes | Dyomic DY-375XL UV-MegStokes | Dyomic DY-380XL UV-MegStokes | Dyomic DY-395XL UV-MegStokes | Dyomic DY-405 | Dyomic DY-415 | Dyomic DY-430 | Dyomic DY-431 | Dyomic DY-490 | Dyomic DY-495 | Dyomic DY-505 | Dyomic DY-530 | Dyomic DY-547 | Dyomic DY-547P1 | Dyomic DY-548 | Dyomic DY-549P1 | Dyomic DY-550 | Dyomic DY-554 | Dyomic DY-555 | Dyomic DY-556 | Dyomic DY-560 | Dyomic DY-591 | Dyomic DY-594 | Dyomic DY-605 | Dyomic DY-610 | Dyomic DY-615 | Dyomic DY-630 | Dyomic DY-631 | Dyomic DY-632 | Dyomic DY-633 | Dyomic DY-634 | Dyomic DY-635 | Dyomic DY-636 | Dyomic DY-639P1 | Dyomic DY-647 | Dyomic DY-647P1 | Dyomic DY-648 | Dyomic DY-648P1 | Dyomic DY-649P1 | Dyomic DY-650 | Dyomic DY-651 | Dyomic DY-652 | Dyomic DY-654 | Dyomic DY-675 | Dyomic DY-676 | Dyomic DY-677 | Dyomic DY-678 | Dyomic DY-679 | Dyomic DY-679P1 | Dyomic DY-680 | Dyomic DY-681 | Dyomic DY-682 | Dyomic DY-700 Near Infrared | Dyomic DY-701 Near Infrared | Dyomic DY-703 Near Infrared | Dyomic DY-704 Near Infrared | Dyomic DY-730 Near Infrared | Dyomic DY-731 Near Infrared | Dyomic DY-732 Near Infrared | Dyomic DY-734 Near Infrared | Dyomic DY-749 Near Infrared | Dyomic DY-750 Near Infrared | Dyomic DY-751 Near Infrared | Dyomic DY-752 Near Infrared | Dyomic DY-754 Near Infrared | Dyomic DY-776 Near Infrared | Dyomic DY-777 Near Infrared | Dyomic DY-778 Near Infrared | Dyomic DY-780 Near Infrared | Dyomic DY-781 Near Infrared | Dyomic DY-782 Near Infrared | Dyomic DY-800 Near Infrared | Dyomic DY-831 Near Infrared | Dyomic DYQ-1 Quencher | Dyomic DYQ-2 Quencher | Dyomic DYQ-4 Quencher | Dyomic DYQ-425 Quencher | Dyomic DYQ-505 Quencher | Dyomic DYQ-660 | Dyomic DYQ-661 | Dyomic DYQ-700 Quencher
• Epoch Dyes
• Eterneon Dyes
• Fluorescein Dye
  • 6-FAM dT | 6-FAM Internal | 6-FAM Terminal | 6-FITC | FAM TEG Azide | HEX, Hexachlorofluorescein | JOE, 4-5-Dichloro carboxy fluorescein | Oregon Green 488 | TET, Tetrachlorofulorescein
• Fluorescent Protein Labels
  • Allophycocyanin (APC) | B-Phycoerythrin B-PE | Cyan Fluorescent Protein (CFP) | Green Fluorescednt PRotein (GFP) | Red Fluorescent Protein (RFP)
• Fluorogenic Enzyme Substrate Oligo Labeling: Coumarin and Coumarin Derivatives
  • 3-Cyano-7-Ethoxycoumarin | Coumarin | DiFMUP (6,8-Difluoro-4-Methylumbelliferyl Phosphate) | MUG (4-Methylumbelliferyl β-D-Galactopyranoside) | MUP (4-Methylumbelliferyl Phosphate)
• Heterocyclic compound
  • Dibromobimane | Monobromobimane
• Janelia Fluor Dyes
  • Janelia Fluor® Dyesについて | Janelia 525
• LightCycler Dye Oligo Labeling
  • LightCycler Red 610 | LightCycler Red 640 | LightCycler Red 670 | LightCycler Red 705
• Molecular Probes Dyes
  • 2′,7′-Dichloro-fluorescein | Acridine Orange Dye | AMCA-X SE (6-((7-amino-4-methylcoumarin-3-acetyl)amino)hexanoic acid | Bimane | Cascade Blue | Cascade Yellow | Dansyl | Dapoxyl dye | Dialkylaminocoumarin | Eosin-5-Isothiocyanate | Hydroxycoumarin | Marina Blue | Methoxycoumarin | NBD | Oregon Green 514 | PyMPO | Pyrene dye | QSY 35® Quencher
• Other Fluorescent Dye Labeling: Cyan 500 NHS
• Oyster Dyes
  • Oyster® 488 | Oyster® 550 | Oyster® 555 | Oyster® 647 | Oyster® 650 | Oyster® 680 | Oyster® 800
• Pacific Dye Oligo Labeling
  • Pacific Blue | Pacific Green | Pacific Orange
• Qdot Probes
• Quasar Dyes
  • Quasar 570 | Quasar 670 | Quasar 705
• Redox Oligo Labels: ATTO MB2 Redox-dye
• Rhodamine Dye Oligo Labeling
  • 6-TAMRA, Carboxytetramethylrhodamine | Rhodamine 6G | Rhodamine Green | TAMRA-dT, Carboxytetramethylrhodamine-dT | Texas Red

Quencher

• ATTO 540Q, 580Q, 612Q Quencher
• Black Hole Quencher – BHQ1, BHQ2, BHQ3
• BlackBerry® Quencher – BBQ-650®
• Dabcyl Quencher
• Dyomic DYQ-1, DYQ-2, DYQ-4, DYQ-425, DYQ-505, DYQ-660, DYQ-661, DYQ-700 Quencher
• DyQ 1, DyQ 2, DyQ 3, DyQ 4, DyQ 425, DyQ 505, DyQ 660, DyQ 661, DyQ 700
• Epoch Eclipse™ Quencher
• EQ0, EQ1, EQ2 Quencher
• IQ4 Quencher
• QSY 21®, QSY 35®, QSY 7®, QSY 9® Quencher

Biotin and Other Non-Fluorescent Conjugates

• Acridine
• Azobenzene
• Biotin
• Biotin TEG
• Desthiobiotin TEG
• DNP-TEG
• dT-Biotin
• Dual Biotin
• PC Biotin
• α-Tocopherol-TEG

Other Labels and Conjugates

• 2,2′-Dipicolylamine
• Anthraquinone, Anthraquinone-C6
• Dicarboxymethylene Blue
• Digoxigenin
• DNP (2,4-dinitrophenyl)
• Doxorubicin
• Ferrocene
• Monocarboxymethylene Blue
• Nitrilotriacetate (NTA)
• SNAP Tag Ligand, Benzylguanine (BG)
• Steary, lipophilic Carrier
• Streptavidin

Photocleavable

• 光切断性オリゴヌクレオチド修飾について
• Photocleavable PC Amino Linker | Photocleavable PC Linker | Photocleavable PC Spacer | Photocleavable Alkyne NHS ester

Photoactivation

• 3-cyanovinylcarbazole nucleoside CNVK Ultrafast Photo Cross-Linker
• NPOM-caged dT

Phosphorylation

• リン酸化オリゴヌクレオチドの合成について
• 2′ Phosphate
• 2′ Thiophosphate
• 3′ Phosphate
• 3′ Thiophosphate
• 5′ Phosphate
• 5′ Thiophosphate
• Diphosphosphate

見積もりのご依頼はこちら | DNA合成 | RNA合成

Cis-Syn Thymine dimer [Cis TT]

Dendrimer Branch Oligos

• オリゴデンドリマーについて
• Asymmetrical Doubler Branch
• Long Trebler Branch
• Symmetric Doubler Branch
• Trebler Branch

Branch Comb-Like Oligo

Click Chemistry

• クリックケミストリーについて
• 1-Ethynyl dSpacer
• 5-Ethynyl dU
• 5-TAMRA Azide
• Alkyne C15, C8 dC (5-Octadiynyl dC), C8 dT (Octadiynyl dT), C8 dU (5-Octadiynyl dU), C8-TIPS dC, C8-TIPS dT, C9, NHS Ester (Hexynoic Acid), PEG NHS (Alkyne C2 NHS), PEG3, PEG4, PEG5 NHS, PEG8, Serinol
• Alkynyl-Modifier C6-dT
• Azide C3, C4 NHS, dT, Azide
• Azido PEG4, PEG8, Propylamine
• Azidobutyrate NHS
• Azidocoumarin NHS | Azidocoumarin spacer 12 & 6
• BCN-PEG12, BCN-PEG2, BCN-PEG3, BCN-PEG4, BCN-PEG8 NHS
• Biotin TEG Azide
• Bromohexyl Amidite
• DBCO C6 NHS, Copper-Free, NHS, PEG1 NHS, PEG4 NHS, PEG5 NHS, PEG8 NHS
• DBCO-dT | DBCO-Serinol | DBCO-TEG Cyclooctyne
• Desthiobiotin TEG Azide
• Hex Azide
• Hexynyl Alkyne
• Iodo-dT
• Methyltetrazine NHS, PEG24 NHS, PEG5 NHS, PEG8 NHS
• Propargyl NHS, PEG1 NH, PEG3 NHS, PEG4 NHS, PEG7 NHS, PEG8 NHS
• Propargyl-5-Me-dC
• Propargyloxy dU
• Psoralen Azide
• TCO NHS
• TCO-PEG24 NHS
• TCO-PEG4
• TEMPO Spin Label
• TEMPO-TEG Spin Label
• TET Azide
• Tetrazine NHS and Tetrazine PEG5

Oligo Bioconjugation

Enzyme Labeled Probe

• オリゴ・酵素コンジュゲートについて
• Alkaline Phosphatase AP
• Horseradish Peroxidase HRP

Macrocyclic Chelation

• DOTA, Tetraazacyclododecane-1,4,7,10-tetraacetic acid
• NOTA, 1,4,7-triazacyclononane-N,N’,N”-triacetic acid
• TETA, 1,4,8,11-tetraazacyclotetradecane-N,N’,N”,N”’-tetraacetic acid
• tm-DOTA

Terminal Cap

• 5’キャップ付きオリゴヌクレオチドについて
• 5′ Adenylation | 5′ Guanosine-triphosphate Cap | 5′ N7-Methylguanosine-triphosphate Cap | 5′ Pyrene Cap | 5′ Trimethyoxystilbene | 5′ Triphosphate | 5′ Uaq Cap

オリゴDNA修飾の関連製品・サービス

• DNAオリゴ合成
• RNAの修飾
• コンジュゲーション (ヌクレオチドとペプチドなど)

修飾オリゴDNAのお問い合わせ・ご注文フォーム

価格や納期はお気軽にお問い合わせください。
Supplied by Bio-Synthesis or Shanghai Generay Biotech